diff --git a/radio/1.0/vts/functional/vts_test_util.cpp b/radio/1.0/vts/functional/vts_test_util.cpp
index fc37201..5b31acc 100644
--- a/radio/1.0/vts/functional/vts_test_util.cpp
+++ b/radio/1.0/vts/functional/vts_test_util.cpp
@@ -83,6 +83,13 @@
     return hasFeature;
 }
 
+bool isSsSsEnabled() {
+    // Do not use checkSubstringInCommandOutput("getprop persist.radio.multisim.config", "")
+    // until b/148904287 is fixed. We need exact matching instead of partial matching. (i.e.
+    // by definition the empty string "" is a substring of any string).
+    return !isDsDsEnabled() && !isTsTsEnabled();
+}
+
 bool isDsDsEnabled() {
     return testing::checkSubstringInCommandOutput("getprop persist.radio.multisim.config", "dsds");
 }
diff --git a/radio/1.0/vts/functional/vts_test_util.h b/radio/1.0/vts/functional/vts_test_util.h
index eeb1d29..fa338a3 100644
--- a/radio/1.0/vts/functional/vts_test_util.h
+++ b/radio/1.0/vts/functional/vts_test_util.h
@@ -80,12 +80,17 @@
 bool deviceSupportsFeature(const char* feature);
 
 /*
- * Check if device is in DSDS.
+ * Check if device is in SsSs (Single SIM Single Standby).
+ */
+bool isSsSsEnabled();
+
+/*
+ * Check if device is in DSDS (Dual SIM Dual Standby).
  */
 bool isDsDsEnabled();
 
 /*
- * Check if device is in TSTS.
+ * Check if device is in TSTS (Triple SIM Triple Standby).
  */
 bool isTsTsEnabled();
 
diff --git a/radio/1.6/vts/functional/radio_hidl_hal_test.cpp b/radio/1.6/vts/functional/radio_hidl_hal_test.cpp
index 5d514a0..00f4468 100644
--- a/radio/1.6/vts/functional/radio_hidl_hal_test.cpp
+++ b/radio/1.6/vts/functional/radio_hidl_hal_test.cpp
@@ -16,8 +16,39 @@
 
 #include <radio_hidl_hal_utils_v1_6.h>
 
+bool isServiceValidForDeviceConfiguration(hidl_string& serviceName) {
+    if (isSsSsEnabled()) {
+        // Device is configured as SSSS.
+        if (serviceName != RADIO_SERVICE_SLOT1_NAME) {
+            ALOGI("%s instance is not valid for SSSS device.", serviceName.c_str());
+            return false;
+        }
+    } else if (isDsDsEnabled()) {
+        // Device is configured as DSDS.
+        if (serviceName != RADIO_SERVICE_SLOT1_NAME && serviceName != RADIO_SERVICE_SLOT2_NAME) {
+            ALOGI("%s instance is not valid for DSDS device.", serviceName.c_str());
+            return false;
+        }
+    } else if (isTsTsEnabled()) {
+        // Device is configured as TSTS.
+        if (serviceName != RADIO_SERVICE_SLOT1_NAME && serviceName != RADIO_SERVICE_SLOT2_NAME &&
+            serviceName != RADIO_SERVICE_SLOT3_NAME) {
+            ALOGI("%s instance is not valid for TSTS device.", serviceName.c_str());
+            return false;
+        }
+    }
+    return true;
+}
+
 void RadioHidlTest_v1_6::SetUp() {
-    radio_v1_6 = android::hardware::radio::V1_6::IRadio::getService(GetParam());
+    hidl_string serviceName = GetParam();
+
+    if (!isServiceValidForDeviceConfiguration(serviceName)) {
+        ALOGI("Skipped the test due to device configuration.");
+        GTEST_SKIP();
+    }
+
+    radio_v1_6 = android::hardware::radio::V1_6::IRadio::getService(serviceName);
     ASSERT_NE(nullptr, radio_v1_6.get());
 
     radioRsp_v1_6 = new (std::nothrow) RadioResponse_v1_6(*this);
diff --git a/radio/1.6/vts/functional/radio_hidl_hal_utils_v1_6.h b/radio/1.6/vts/functional/radio_hidl_hal_utils_v1_6.h
index 3185f98..54c2977 100644
--- a/radio/1.6/vts/functional/radio_hidl_hal_utils_v1_6.h
+++ b/radio/1.6/vts/functional/radio_hidl_hal_utils_v1_6.h
@@ -48,7 +48,9 @@
 #define MODEM_EMERGENCY_CALL_ESTABLISH_TIME 3
 #define MODEM_EMERGENCY_CALL_DISCONNECT_TIME 3
 
-#define RADIO_SERVICE_NAME "slot1"
+#define RADIO_SERVICE_SLOT1_NAME "slot1"  // HAL instance name for SIM slot 1 or single SIM device
+#define RADIO_SERVICE_SLOT2_NAME "slot2"  // HAL instance name for SIM slot 2 on dual SIM device
+#define RADIO_SERVICE_SLOT3_NAME "slot3"  // HAL instance name for SIM slot 3 on triple SIM device
 
 class RadioHidlTest_v1_6;
 extern ::android::hardware::radio::V1_5::CardStatus cardStatus;