diff --git a/src/macros.h b/src/macros.h
index caaca9a..737eddf 100644
--- a/src/macros.h
+++ b/src/macros.h
@@ -231,7 +231,7 @@
 #if defined(UNIX) || defined(VMS)  /* open in rw------- mode */
 # define mch_open_rw(n, f)	mch_open((n), (f), (mode_t)0600)
 #else
-# if defined(MSDOS) || defined(MSWIN) || defined(OS2)  /* open read/write */
+# if defined(MSDOS) || defined(MSWIN)  /* open read/write */
 #  define mch_open_rw(n, f)	mch_open((n), (f), S_IREAD | S_IWRITE)
 # else
 #  define mch_open_rw(n, f)	mch_open((n), (f), 0)