diff --git a/runtime/filetype.vim b/runtime/filetype.vim
index 2c46c57..fe12047 100644
--- a/runtime/filetype.vim
+++ b/runtime/filetype.vim
@@ -1976,6 +1976,10 @@
 " Protocols
 au BufNewFile,BufRead */etc/protocols		setf protocols
 
+" Nvidia PTX (Parallel Thread Execution)
+" See https://docs.nvidia.com/cuda/parallel-thread-execution/
+au BufNewFile,BufRead *.ptx			setf ptx
+
 " Purescript
 au BufNewFile,BufRead *.purs			setf purescript
 
diff --git a/runtime/ftplugin/ptx.vim b/runtime/ftplugin/ptx.vim
new file mode 100644
index 0000000..12b127c
--- /dev/null
+++ b/runtime/ftplugin/ptx.vim
@@ -0,0 +1,16 @@
+" Vim filetype plugin file
+" Language:	Nvidia PTX (Parellel Thread Execution)
+" Maintainer:	Yinzuo Jiang <jiangyinzuo@foxmail.com>
+" Last Change:	2024-12-05
+
+if exists("b:did_ftplugin")
+  finish
+endif
+
+let b:did_ftplugin = 1
+
+" Comments in PTX follow C/C++ syntax
+" See: https://docs.nvidia.com/cuda/parallel-thread-execution/#syntax
+setlocal commentstring=//\ %s
+
+let b:undo_ftplugin = 'setl commentstring<'
diff --git a/runtime/syntax/ptx.vim b/runtime/syntax/ptx.vim
new file mode 100644
index 0000000..98de4ff
--- /dev/null
+++ b/runtime/syntax/ptx.vim
@@ -0,0 +1,52 @@
+" Vim syntax file
+" Language: Nvidia PTX (Parallel Thread Execution)
+" Maintainer: Yinzuo Jiang <jiangyinzuo@foxmail.com>
+" Latest Revision: 2024-12-05
+
+if exists("b:current_syntax")
+  finish
+endif
+
+let s:cpo_save = &cpo
+set cpo&vim
+
+syntax iskeyword .,_,a-z,48-57
+
+" https://docs.nvidia.com/cuda/parallel-thread-execution/#directives
+syntax keyword ptxFunction .entry .func
+syntax keyword ptxDirective .branchtargets .file .loc .secion .maxnctapersm .maxnreg .minnctapersm .noreturn .pragma .reqntid .target .version .weak
+syntax keyword ptxOperator .address_size .alias .align .callprototype .calltargets
+syntax keyword ptxStorageClass .common .const .extern .global .local .param .reg .sreg .shared .tex .visible
+syntax keyword ptxType .explicitcluster .maxclusterrank .reqnctapercluster
+
+" https://docs.nvidia.com/cuda/parallel-thread-execution/#fundamental-types
+" signed integer
+syntax keyword ptxType .s8 .s16 .s32 .s64
+" unsigned integer
+syntax keyword ptxType .u8 .u16 .u32 .u64
+" floating-point
+syntax keyword ptxType .f16 .f16x2 .f32 .f64
+" bits (untyped)
+syntax keyword ptxType .b8 .b16 .b32 .b64 .b128
+" predicate
+syntax keyword ptxType .pred
+
+" https://docs.nvidia.com/cuda/parallel-thread-execution/#instruction-statements
+syntax keyword ptxStatement ret
+
+syntax region  ptxCommentL start="//" skip="\\$" end="$" keepend
+syntax region ptxComment matchgroup=ptxCommentStart start="/\*" end="\*/" extend
+
+hi def link ptxFunction Function
+hi def link ptxDirective Keyword
+hi def link ptxOperator Operator
+hi def link ptxStorageClass StorageClass
+hi def link ptxType Type
+hi def link ptxStatement Statement
+
+hi def link ptxCommentL ptxComment
+hi def link ptxCommentStart ptxComment
+hi def link ptxComment Comment
+
+let &cpo = s:cpo_save
+unlet s:cpo_save