diff --git a/src/buffer.c b/src/buffer.c
index 24da829..81bdb31 100644
--- a/src/buffer.c
+++ b/src/buffer.c
@@ -1706,6 +1706,7 @@
 #endif
     bufref_T	newbufref;
     bufref_T	prevbufref;
+    int		valid;
 
     setpcmark();
     if ((cmdmod.cmod_flags & CMOD_KEEPALT) == 0)
@@ -1763,13 +1764,19 @@
     // An autocommand may have deleted "buf", already entered it (e.g., when
     // it did ":bunload") or aborted the script processing.
     // If curwin->w_buffer is null, enter_buffer() will make it valid again
-    if ((buf_valid(buf) && buf != curbuf
+    valid = buf_valid(buf);
+    if ((valid && buf != curbuf
 #ifdef FEAT_EVAL
 		&& !aborting()
 #endif
 	) || curwin->w_buffer == NULL)
     {
-	enter_buffer(buf);
+	// If the buffer is not valid but curwin->w_buffer is NULL we must
+	// enter some buffer.  Using the last one is hopefully OK.
+	if (!valid)
+	    enter_buffer(lastbuf);
+	else
+	    enter_buffer(buf);
 #ifdef FEAT_SYN_HL
 	if (old_tw != curbuf->b_p_tw)
 	    check_colorcolumn(curwin);
@@ -2288,8 +2295,7 @@
     clear_string_option(&buf->b_p_vsts);
     vim_free(buf->b_p_vsts_nopaste);
     buf->b_p_vsts_nopaste = NULL;
-    vim_free(buf->b_p_vsts_array);
-    buf->b_p_vsts_array = NULL;
+    VIM_CLEAR(buf->b_p_vsts_array);
     clear_string_option(&buf->b_p_vts);
     VIM_CLEAR(buf->b_p_vts_array);
 #endif
diff --git a/src/testdir/test_quickfix.vim b/src/testdir/test_quickfix.vim
index fb6d21f..07fdb96 100644
--- a/src/testdir/test_quickfix.vim
+++ b/src/testdir/test_quickfix.vim
@@ -979,6 +979,7 @@
   call assert_fails('lrewind', 'E924:')
 
   augroup! testgroup
+  delfunc R
 endfunc
 
 func Test_locationlist_cross_tab_jump()
@@ -5835,4 +5836,20 @@
   %bw!
 endfunc
 
+" Weird sequence of commands that caused entering a wiped-out buffer
+func Test_lopen_bwipe()
+  func R()
+    silent! tab lopen
+    e x
+    silent! lfile
+  endfunc
+
+  cal R()
+  cal R()
+  cal R()
+  bw!
+  delfunc R
+endfunc
+
+
 " vim: shiftwidth=2 sts=2 expandtab
diff --git a/src/version.c b/src/version.c
index 978e869..d8b3d4b 100644
--- a/src/version.c
+++ b/src/version.c
@@ -747,6 +747,8 @@
 static int included_patches[] =
 {   /* Add new patch number below this line */
 /**/
+    4281,
+/**/
     4280,
 /**/
     4279,