diff --git a/src/configure.in b/src/configure.in
index 6ffc675..7b5e08f 100644
--- a/src/configure.in
+++ b/src/configure.in
@@ -891,9 +891,9 @@
 
 	PYTHON_LIBS="${vi_cv_path_python_plibs}"
 	if test "${vi_cv_path_python_pfx}" = "${vi_cv_path_python_epfx}"; then
-	  PYTHON_CFLAGS="-I${vi_cv_path_python_pfx}/include/python${vi_cv_var_python_version}"
+	  PYTHON_CFLAGS="-I${vi_cv_path_python_pfx}/include/python${vi_cv_var_python_version} -DPYTHON_HOME=\\\"${vi_cv_path_python_pfx}\\\""
 	else
-	  PYTHON_CFLAGS="-I${vi_cv_path_python_pfx}/include/python${vi_cv_var_python_version} -I${vi_cv_path_python_epfx}/include/python${vi_cv_var_python_version}"
+	  PYTHON_CFLAGS="-I${vi_cv_path_python_pfx}/include/python${vi_cv_var_python_version} -I${vi_cv_path_python_epfx}/include/python${vi_cv_var_python_version} -DPYTHON_HOME=\\\"${vi_cv_path_python_pfx}\\\""
 	fi
 	PYTHON_SRC="if_python.c"
 	dnl For Mac OSX 10.2 config.o is included in the Python library.
@@ -905,7 +905,7 @@
 	if test "${vi_cv_var_python_version}" = "1.4"; then
 	   PYTHON_OBJ="$PYTHON_OBJ objects/py_getpath.o"
 	fi
-	PYTHON_GETPATH_CFLAGS="-DPYTHONPATH='\"${vi_cv_path_pythonpath}\"' -DPREFIX='\"${vi_cv_path_python_pfx}\"' -DEXEC_PREFIX='\"${vi_cv_path_python_epfx}\"'"
+    PYTHON_GETPATH_CFLAGS="-DPYTHONPATH='\"${vi_cv_path_pythonpath}\"' -DPREFIX='\"${vi_cv_path_python_pfx}\"' -DEXEC_PREFIX='\"${vi_cv_path_python_epfx}\"'"
 
 	dnl On FreeBSD linking with "-pthread" is required to use threads.
 	dnl _THREAD_SAFE must be used for compiling then.
@@ -1063,9 +1063,9 @@
 
       PYTHON3_LIBS="${vi_cv_path_python3_plibs}"
       if test "${vi_cv_path_python3_pfx}" = "${vi_cv_path_python3_epfx}"; then
-        PYTHON3_CFLAGS="-I${vi_cv_path_python3_pfx}/include/python${vi_cv_var_python3_version}"
+        PYTHON3_CFLAGS="-I${vi_cv_path_python3_pfx}/include/python${vi_cv_var_python3_version} -DPYTHON3_HOME=L\\\"${vi_cv_path_python3_pfx}\\\""
       else
-        PYTHON3_CFLAGS="-I${vi_cv_path_python3_pfx}/include/python${vi_cv_var_python3_version} -I${vi_cv_path_python3_epfx}/include/python${vi_cv_var_python3_version}"
+        PYTHON3_CFLAGS="-I${vi_cv_path_python3_pfx}/include/python${vi_cv_var_python3_version} -I${vi_cv_path_python3_epfx}/include/python${vi_cv_var_python3_version} -DPYTHON3_HOME=L\\\"${vi_cv_path_python3_pfx}\\\""
       fi
       PYTHON3_SRC="if_python3.c"
       dnl For Mac OSX 10.2 config.o is included in the Python library.
@@ -1143,9 +1143,9 @@
 if test "$python_ok" = yes && test "$python3_ok" = yes; then
   AC_DEFINE(DYNAMIC_PYTHON)
   AC_DEFINE(DYNAMIC_PYTHON3)
-  AC_MSG_CHECKING(whether we can do without RTLD_GLOBAL)
+  AC_MSG_CHECKING(whether we can do without RTLD_GLOBAL for Python)
   cflags_save=$CFLAGS
-  CFLAGS="$CFLAGS $PYTHON3_CFLAGS"
+  CFLAGS="$CFLAGS $PYTHON_CFLAGS"
   ldflags_save=$LDFLAGS
   LDFLAGS="$LDFLAGS -ldl"
   AC_RUN_IFELSE([
@@ -1156,15 +1156,17 @@
      * Only the first pyhton version used will be switched on.
      */
 
-    int no_rtl_global_needed_for(char *python_instsoname)
+    int no_rtl_global_needed_for(char *python_instsoname, char *prefix)
     {
       int needed = 0;
       void* pylib = dlopen(python_instsoname, RTLD_LAZY);
       if (pylib != 0)
       {
+          void (*pfx)(char *home) = dlsym(pylib, "Py_SetPythonHome");
           void (*init)(void) = dlsym(pylib, "Py_Initialize");
           int (*simple)(char*) = dlsym(pylib, "PyRun_SimpleString");
           void (*final)(void) = dlsym(pylib, "Py_Finalize");
+          (*pfx)(prefix);
           (*init)();
           needed = (*simple)("import termios") == -1;
           (*final)();
@@ -1176,13 +1178,60 @@
     int main(int argc, char** argv)
     {
       int not_needed = 0;
-      if (no_rtl_global_needed_for("libpython2.7.so.1.0") && no_rtl_global_needed_for("libpython3.1.so.1.0"))
+      if (no_rtl_global_needed_for("${python_INSTSONAME}", "${vi_cv_path_python_pfx}"))
             not_needed = 1;
       return !not_needed;
     }],
     [AC_MSG_RESULT(yes);AC_DEFINE(PY_NO_RTLD_GLOBAL)], [AC_MSG_RESULT(no)])
+
   CFLAGS=$cflags_save
   LDFLAGS=$ldflags_save
+
+  AC_MSG_CHECKING(whether we can do without RTLD_GLOBAL for Python3)
+  cflags_save=$CFLAGS
+  CFLAGS="$CFLAGS $PYTHON3_CFLAGS"
+  ldflags_save=$LDFLAGS
+  LDFLAGS="$LDFLAGS -ldl"
+  AC_RUN_IFELSE([
+    #include <dlfcn.h>
+    #include <wchar.h>
+    /* If this program fails, then RTLD_GLOBAL is needed.
+     * RTLD_GLOBAL will be used and then it is not possible to
+     * have both python versions enabled in the same vim instance.
+     * Only the first pyhton version used will be switched on.
+     */
+
+    int no_rtl_global_needed_for(char *python_instsoname, wchar_t *prefix)
+    {
+      int needed = 0;
+      void* pylib = dlopen(python_instsoname, RTLD_LAZY);
+      if (pylib != 0)
+      {
+          void (*pfx)(wchar_t *home) = dlsym(pylib, "Py_SetPythonHome");
+          void (*init)(void) = dlsym(pylib, "Py_Initialize");
+          int (*simple)(char*) = dlsym(pylib, "PyRun_SimpleString");
+          void (*final)(void) = dlsym(pylib, "Py_Finalize");
+          (*pfx)(prefix);
+          (*init)();
+          needed = (*simple)("import termios") == -1;
+          (*final)();
+          dlclose(pylib);
+      }
+      return !needed;
+    }
+
+    int main(int argc, char** argv)
+    {
+      int not_needed = 0;
+      if (no_rtl_global_needed_for("${python3_INSTSONAME}", L"${vi_cv_path_python3_pfx}"))
+            not_needed = 1;
+      return !not_needed;
+    }],
+    [AC_MSG_RESULT(yes);AC_DEFINE(PY3_NO_RTLD_GLOBAL)], [AC_MSG_RESULT(no)])
+
+  CFLAGS=$cflags_save
+  LDFLAGS=$ldflags_save
+
   PYTHON_SRC="if_python.c"
   PYTHON_OBJ="objects/if_python.o"
   PYTHON_CFLAGS="$PYTHON_CFLAGS -DDYNAMIC_PYTHON_DLL=\\\"${python_INSTSONAME}\\\""